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Product Details 基本信息 ISBN-13 书号 9789811369117 Author 作者 Kawamoto Format 版本 精装 Pages Number 页数 122页 Publication Date 出版日期 2019-03-19 Language 语种 英语 Book Contents 内容简介 This book presents a novel method of synthesizing sequence-specific DNA binding pyrrole–imidazole (Py–Im) polyamides and demonstrates polyamides targeting longer base pairs than those previously reported and their cellular application. It discusses the development of the facile synthetic method of tandem hairpin Py–Im polyamides and the method of visualizing telomeres under mild conditions without harsh denaturation, as well as research resulting in the synthesis not only of previously reported tandem dimer polyamides but also longer tandem trimer and tetramer polyamides. Using fluorescently labeled tandem hairpin Py–Im polyamides targeting a human telomere repetitive sequence, the author successfully stained telomer
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