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图书信息 书号: 9781441936707 作者: Ronald G Ross 装帧: 平装-胶订 页数: 726页 出版社: Springer Us 尺寸: 25.4 x 17.8 x 2.5 cm 出版日期: 2010-10-29 重量: 1362g 语种: 其它(含多语) 内容简介 The last two years have witnessed a continuation in the breakthrough sh
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Product Details 基本信息 ISBN-13 书号 9781588291998 Author 作者 Ronald G. Wiley Format 版本 精装 Pages Number 页数 312页 Publisher 出版社 Humana Press Publication Date 出版日期 2005-03-22 Language 语种 英语 Book Contents 内容简介 Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer’s disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuro
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